MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport
نویسندگان
چکیده
منابع مشابه
Low density lipoprotein-activated lysolecithin acylation by human plasma lecithin-cholesterol acyltransferase. Identity of lysolecithin acyltransferase and lecithin-cholesterol acyltransferase.
There is in normal plasma an enzyme activity which converts labeled lysolecithin to lecithin by an energy-independent low density lipoprotein-activated pathway. Studies were undertaken to compare the identity of this enzyme with lecithin-cholesterol acyltransferase. During purification of the enzyme by ultracentrifugation and by chromatography on high density lipoprotein affinity column, DEAE-S...
متن کاملHigh-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis
Epidemiological data clearly show the existence of a strong inverse correlation between plasma high-density lipoprotein cholesterol (HDL-C) concentrations and the incidence of coronary heart disease. This relation is explained by a number of atheroprotective properties of HDL, first of all the ability to promote macrophage cholesterol transport. HDL are highly heterogeneous and are continuously...
متن کاملLecithin--cholesterol acyltransferase and the lipoprotein abnormalities of obstructive jaundice.
1. We have studied the plasma lipoprotein abnormalities in obstructive jaundice to test the hypothesis that the abnormalities would correlate with plasma lecithin--cholesterol acyltransferase activity. 2. Very-low-density lipoproteins (VLDL) were normal in composition and had a normal pre-beta electrophoretic mobility when lecithin--cholesterol acyltransferase activity was high. When it was low...
متن کاملEffect of recombinant human lecithin cholesterol acyltransferase infusion on lipoprotein metabolism in mice.
Lecithin cholesterol acyl transferase (LCAT) deficiency is associated with low high-density lipoprotein (HDL) and the presence of an abnormal lipoprotein called lipoprotein X (Lp-X) that contributes to end-stage renal disease. We examined the possibility of using LCAT an as enzyme replacement therapy agent by testing the infusion of human recombinant (r)LCAT into several mouse models of LCAT de...
متن کاملSerum cholesterol esterification in liver disease. Combined determinations of lecithin: cholesterol acyltransferase and lipoprotein-X.
Indireet evidence suggests that lecithin: choles· terol acyltransferase (LCAT) is synthesized in the liver. There are, however, controversial reports in the literature correlating LCAT activity with various forms of liver disease. The purpose of this study was to determine LCAT activity in icteric pa· tients. These were classified not only by the conventional methods, but also with respect to t...
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ژورنال
عنوان ژورنال: Journal of the American Heart Association
سال: 2021
ISSN: 2047-9980
DOI: 10.1161/jaha.119.014572